ABSTRACT
BACKGROUND: Colorectal cancer is a common, deadly disease with different incidence rates in different parts of the world. The present study aims to investigate the clinical presentations, colonoscopic findings, and family history of colorectal cancer in the city of Khorramabad, Iran
METHODS: This cross-sectional study, conducted in 2013, included 112 patients diag-nosed with colorectal cancer by colonoscopy with pathological confirmation in addition to 112 individuals matched with patients for age and gender. Controls were chosen from the outpatients admitted to the Skin and Eye Clinics of Sho-hadaAshayer Hospital in Khorramabad who had no gastrointestinal diseases. A self-generated questionnaire was used to assess family history of smoking and gastrointestinal cancer history in immediate relatives of subjects from both groups. Fisher's exact test and odds ratios [OR] were used to analyze the data
RESUETS: Based on the findings of this study, the most common clinical presentation in the patients was abdominal pain [67.9%]
The sigmoid colon [40%] was the most common anatomical site of the tumor in men; the rectum [34.6%] and sigmoid colon [34.6%] were the most common sites in women, which was not statistically significant [p=0.21]
There were 11 [19.6%] patients and 2 [3.6%] individuals in the control group who reported a history of colorectal cancer in their immediate relatives, which was statistically significant [p=0.008]
CONCEUSION: In this study, left-sided colon cancer was more common. Subjects with colon cancer had more [positive FHx. This indicated that genetic factors, in addition to environmental factors, could increase the incidence of colorectal cancer in a community. A better identification of these factors would result in better control and management of this disease
ABSTRACT
Acute upper gastrointestinal bleeding [UGIB] is a common medical emergency and is known as one of the main causes of mortality and morbidity. This research was conducted to study the causes and risk factors for UGIB, in a referral center. In this cross sectional study, carried out in a one year period, all patients with acute UGIB living in Khorramabad city and surrounding area, entered the study. A control group with age and sex matched was selected from outpatient visits and their relatives who had referred to hospital clinics. Data collecting tool was a self-made questionnaire, demographic, clinical manifestations and endoscopic findings. The data was analyzed using chi-square test, Fisher exact test and Odds ratio estimation. Sixty-two patients with acute UGIB were studied, 67.7% of them were males. The mean age of patients was 54.5 +/- 12.1. The most common causes of acute UGIB were peptic [42.7%], erosive gastritis [19.8%] and esophageal varices [19.8%]. 29%, and 9.7% of patients, and control group had a history of regular consumption of Non Steroidal Anti-Inflammatory Drugs [Odd' s ratio 3.8, CI: 1.3-4.8]. 35.5% of episodes of acute UGIB were in age more than 60 years. Peptic ulcer disease is the most common cause of acute UGIB in our region. Episodes of acute UGIB were correlated with regular NSAIDs use, but not with alcohol consumption, smoking, and gender. Identifying people who are at risk and providing preventive strategies can reduce the rate of this disease and its complications